Which of the following statements is true regarding Hepatitis E Virus (HEV)?

Hepatitis E Virus (HEV) is indeed endemic in certain regions with inadequate sanitation and access to clean water, which significantly contributes to its transmission. The virus is primarily transmitted through the fecal-oral route, often in areas where hygiene practices are poor, leading to outbreaks primarily associated with contaminated water supplies. This makes option B a true statement as it highlights the relationship between HEV infections and environmental factors related to sanitation.

In contrast, while the virus can be detected in blood, it is not primarily spread that way, hence choosing a blood transmission-focused option would be misleading. Moreover, HEV is not known to lead to chronic liver disease like some other hepatitis viruses, notably Hepatitis B and C; it generally causes acute hepatitis and is typically self-limiting. Finally, there are no specific antiviral treatments approved for HEV; management is generally supportive, thereby ruling out the possibility of using antiviral drugs effectively against this virus. Understanding these aspects helps clarify why option B stands correct among the other statements regarding HEV.