What is an important precaution when administering prometazine (Phenergan)?

When administering prometazine (Phenergan), it is crucial to dilute the medication appropriately to minimize the risk of extravasation, which is the unintended leakage of the drug into the surrounding tissue. If the medication is not adequately diluted, it can lead to tissue damage, resulting in complications such as necrosis and severe local irritation.

Promethazine is an antihistamine that can cause vasodilation and, in concentrated forms or when given undiluted, can increase the likelihood of irritation at the injection site. Therefore, proper dilution helps ensure that the medication is delivered safely into the bloodstream, mitigating the risk of adverse reactions associated with extravasation.

While other precautions, such as monitoring for drowsiness, are also important when administering this medication, the key focus in this context is on the safe preparation and administration techniques to prevent harm to the patient. It's essential to follow proper procedures and guidelines concerning the administration of promethazine to promote safe and effective patient care.